Irregular menstrual cycles, infertility, acne, thyroid issues, obesity, unexplained weight loss/gain, fatigue, constipation, diarrhea, numbness and tingling in your hands, high blood pressure, depression, anxiety, extremely dry skin and hair, are unable to tolerate warm/cold temperatures, irregular body fat distribution, frequent urination, extreme thirst, irregular fat distribution, hair loss, hot flashes, excess body hair, painful/heavy periods, spotting, mood swings, irritability, loss of interest in sex, vaginal dryness, vaginal atrophy, loss of body hair, erectile dysfunction (male only), enlarged breast tissue (male only), loss of muscle mass (male only), tumor, adenoma, nodule, insomnia, sleeping too much, or painful joints/muscles.